Can You Overdose on Flexeril? Side Effects & Symptoms

Can You Overdose on Flexeril? Side Effects & Symptoms

Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. The dose of this medicine will be different for different patients. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

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Cyclobenzaprine reduced or abolished skeletal muscle hyperactivity in several animal models. Animal studies indicate that cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle. Evidence suggests that the net effect of cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma (γ) and alpha (α) motor systems. Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation. Hyperpyretic crisis seizures, and deaths have occurred in patients receiving cyclobenzaprine (or structurally similar tricyclic antidepressants) concomitantly with MAO inhibitor drugs. Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation.

Health Concerns

In a pharmacokinetic study of sixteen subjects with hepatic impairment (15 mild, 1 moderate per Child-Pugh score), both AUC and Cmax were approximately double the values seen in the healthy control group. Based on the findings, FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with the 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of FLEXERIL in subjects with moderate to severe impairment is not recommended. In patients with CNS depression, early intubation is advised because of the potential for abrupt deterioration. Seizures should be controlled with benzodiazepines or, if these are ineffective, other anticonvulsants (e.g. phenobarbital, phenytoin). Physostigmine is not recommended except to treat life-threatening symptoms that have been unresponsive to other therapies, and then only in close consultation with a poison control center.

  • Cyclobenzaprine may also be used for purposes not listed in this medication guide.
  • If they’re more severe or don’t go away, talk with your doctor or pharmacist.
  • The overall incidence of adverse reactions among patients in the surveillance program was less than the incidence in the controlled clinical studies.
  • Cyclobenzaprine is a skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin.
  • Taking more may result in adverse Flexeril side effects or overdose.

Multiple drug ingestion (including alcohol) is common in deliberate cyclobenzaprine overdose. As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible. The acute oral LD50 of FLEXERIL is approximately 338 and 425 mg/kg in mice and rats, respectively. The plasma concentration of cyclobenzaprine is increased in the elderly (see CLINICAL PHARMACOLOGY, Pharmacokinetics,Elderly). The elderly may also be more at risk for CNS adverse events such as hallucinations and confusion, cardiac events resulting in falls or other sequelae, drug-drug and drug-disease interactions.

Abuse of cyclobenzaprine is relatively rare but most often occurs in the context of other substance use. Polydrug abuse can cause serious harm, especially when the flexeril qtc combination includes CNS depressing substances such as benzodiazepines and alcohol. The amount of medicine that you take depends on the strength of the medicine.

What should I avoid while taking cyclobenzaprine?

Other drugs may affect cyclobenzaprine, including prescription and over-the-counter medicines, vitamins, and herbal products. Cyclobenzaprine comes as a tablet and an extended-release capsule to take by mouth. The tablet is usually taken with or without food three times a day. The extended-release capsule is usually taken with or without food once a day. Do not take this drug for more than 3 weeks without talking to your doctor.

The medication can loosen muscles to make therapy sessions more comfortable. Chlorzoxazone, a muscle relaxant used to treat muscle spasm and the resulting pain or discomfort, had an estimated 400,000 prescriptions in the United States in 2020. It has been around for many years but is not as commonly prescribed today due to side effects such as dizziness and drowsiness. Flexeril, also known as cyclobenzaprine, is another type of muscle relaxant. It works primarily within the brainstem to reduce tonic somatic motor activity, which ultimately relieves acute musculoskeletal conditions characterized by persistent spasms.

Chlorzoxazone and Flexeril are two such drugs that are prescribed for this purpose. These medications work differently but both have effects on the central nervous system (CNS) to provide relief from painful muscular conditions. Stopping muscle relaxants suddenly can lead to withdrawal symptoms. Anyone with a history of substance abuse should mention this medical history to their doctor. Studies have compared cyclobenzaprine, methocarbamol, and other skeletal muscle relaxants and found that they are equally effective in treating acute musculoskeletal conditions. Cyclobenzaprine is one of the most studied skeletal muscle relaxants, with solid evidence and systematic reviews supporting its effectiveness.

Information for Patients

Cyclobenzaprine is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries. Cyclobenzaprine is in a class of medications called skeletal muscle relaxants. It works by acting in the brain and nervous system to allow the muscles to relax.

Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Both drugs are skeletal muscle relaxants or antispasmodic agents, but they contain different active ingredients. Methocarbamol typically needs to be taken up to 4 times a day, whereas cyclobenzaprine extended-release capsules offer the convenience of once-a-day dosing.

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